Uso de Hormônios. Dois pesos, Duas medidas

 

O uso de hormônios pode ser bom e ruim. Depende do contexto. 
hauhauhauha… Isto é óbvio.

Para demonstrar, dois exemplos recentes:

1. Qaisar R, Renaud G, Hedström Y, Pöllänen E, Ronkainen P, Kaprio J, Alen M, Sipilä S, Artemenko K, Bergquist J, Kovanen V, Larsson L. Hormone replacement therapy improves contractile function and myonuclear organization of single fibres from postmenopausal monozygotic female twin pairs. J Physiol. 2013 Mar 4. [Epub ahead of print]:

Hormone replacement therapy (HRT) treatment improved single fibre force-generating capacity (specific force), without affecting fibre size and speed of contraction, due to fibre type-specific effects on force and number of force-generating cross-bridges.

HRT had a significant effect on the myonuclear organization in slow-twitch muscle fibres, improving the synthetic capacity of the myonuclei and optimizing transport of proteins.

Significant positive effects on regulation of muscle contraction and myonuclear organization were observed at the cellular level in response to HRT with consequences for quality of life in postmenopausal women.

O resumo (não tem a informação, mas foi uso de progesterona e estradiol):

Ageing is associated with a decline in muscle mass and strength leading to increased physical dependency in old age. Postmenopausal women experience a greater decline than men of similar age in parallel with the decrease in female sex steroid hormone production. We recruited six monozygous female twin pairs (55–59 years old) where only one twin pair was on hormone replacement therapy (HRT use = 7.8 ± 4.3 years) to investigate the association of HRT with the cytoplasmic volume supported by individual myonuclei (myonuclear domain (MND) size,) together with specific force at the single fibre level. HRT use was associated with a significantly smaller (∼27%; P < 0.05) mean MND size in muscle fibres expressing the type I but not the IIa myosin heavy chain (MyHC) isoform. In comparison to non-users, higher specific force was recorded in HRT users both in muscle fibres expressing type I (∼27%; P < 0.05) and type IIa (∼23%; P < 0.05) MyHC isoforms. These differences were fibre-type dependent, i.e. the higher specific force in fast-twitch muscle fibres was primarily caused by higher force per cross-bridge while slow-twitch fibres relied on both a higher number and force per cross-bridge. HRT use had no effect on fibre cross-sectional area (CSA), velocity of unloaded shortening (V0) and relative proportion of MyHC isoforms. In conclusion, HRT appears to have significant positive effects on both regulation of muscle contraction and myonuclei organization in postmenopausal women.

Mas e as fibras do tipo 2?? 😉
Exercício físico (de verdade) nelas…

E nada de dança da cadeira, brincar de bexiga e atividades (só) para socialização.

força-idosa
plio-idosa

 

Por outro lado:

2. Lindqvist AS, Moberg T, Eriksson BO, Ehrnborg C, Rosén T, Fahlke C. A retrospective 30-year follow-up study of former Swedish-elite male athletes in power sports with a past anabolic androgenic steroids use: a focus on mental health. Br J Sports Med. 2013 Apr 23. [Epub ahead of print].

BACKGROUND: The knowledge concerning the long-term effect of former anabolic androgenic steroids (AAS)-use on mental health is sparse.
AIM: This study aims to investigate whether previous AAS-use affects mental health, present sociodemographic data, sport activity and substance abuse in a retrospective 30-year follow-up study of former elite athletes.
METHODS: Swedish male-elite power sport athletes (n=683) on the top 10 national ranking lists during any of the years 1960-1979 in wrestling, Olympic lifting, powerlifting and the throwing events in track and field answered a questionnaire.
RESULTS: At least 20% of the former athletes admitted previous AAS-use. They had more often sought professional expertise for mental problems and had used illicit drugs compared to those not having used AAS. The AAS-users also differed in former sport activity pattern compared to non AAS-users.
CONCLUSIONS: It is clear that a relationship exists between use of AAS and mental-health problems. Further studies need to be done in order to clarify this relationship.

 

Vários sabem que não sou contra o uso de EAA. No entanto, uma das primeiras coisas que falo quando as pessoas vêm me perguntar sobre o assunto é: “Você está disposto a lidar com a depressão pós-ciclo?”. Quando a resposta é, rapidamente, “sim”, vejo que a pessoa não está preparada para usar EAA adequadamente 😉

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