No último congresso europeu sobre obesidade (http://www.easo.org/eco2012/) um trabalho de alemães chamou muito a atenção. Ele foi conduzidos com homens entre 38 e 83 anos, e avaliou a terapia de reposição hormonal com testosterona.
O link do trabalho é:
Restoring Testosterone to Normal Levels in Elderly Men Is Efficacious in Weight Reduction. A Follow-Up Study over 5 Years
Farid Saad, Ahmad Haider, Louis Gooren. Bayer Pharma AG, Berlin, Germany; Gulf Medical University School of Medicine, Ajman, United Arab Emirates; Private Practice, Bermerhaven, Germany; VUMC Amsterdam, Amsterdam, Netherlands.
Introduction: Obesity is associated with reduced testosterone, and low testosterone induces weight gain. This study analysed the effects of normalization of serum testosterone in mainly elderly, hypogonadal men.
Methods: Open-label, single-center, cumulative, prospective registry study of 255 men (aged 38 – 83 years, mean 60.6 ± 8.0 years), with testosterone levels between 1.7 –3.5 ng/mL (mean: 2.87 ± 0.4). Cut-off point for testosterone treatment was serum testosterone ≤ 3.5. ng/mL). 215 men were studied for at least 2 years, 182 for 3 years, 148 for 4 and 116 for at least 5 years. They received parenteral testosterone undecanoate 1000 mg/12 weeks after an initial interval of 6 weeks.
Results: After 5 years the following changes were observed: weight (kg) decreased from 106.22 ± 16.93 (minimum: 70, maximum: 139) to 90.07 ± 9.51 (min 74.00, max 115). The statistical significance was p<0.0001 vs baseline and vs the previous year over 5 years indicating a continuous weight loss over the full observation period. Waist circumference (cm) declined from 107.24 ± 9.14 (min 86, max 129) to 98.46 ± 7.39 (min 84, max 117) (p<0.0001 vs baseline and vs the previous year over 5 years). Body mass index (BMI, m/kg2) declined from 33.93 ± 5.54 (min 21.91, max 46.51) to 29.17 ± 3.09 (min 22.7; max 36.71) (p<0.0001 vs baseline and vs the previous year over 5 years). The mean per cent weight loss after 1 year was 4.12 ± 3.48%, after 2 years 7.47 ± 5.01%, after 3 years 9.01 ± 6.5%, after 4 years 11.26 ± 6.76% and after 5 years 13.21 ± 7.24%. At baseline, 96% of men had a waist circumference of ≥ 94 cm. This proportion decreased to 71% after 5 years.
Conclusions: Raising serum testosterone to normal produced loss of body weight, waist circumference and BMI. These improvements were progressive over the full 5 years of the study.
Ou seja, (desconsiderando os conflitos de interesse [envolvimento dos autores com a Bayer]), os resultados apontam o que a gente sabe, mas muita gente esconde: O uso de esteroides anabolizantes androgênicos contribui para a diminuição da gordura corporal.
Por que isto é pouco difundido? A venda de outros medicamentos dá mais lucro para as empresas farmacológicas.