Há bastante tempo as pessoas inteligentes estão falando sobre os benefícios do treinamento intenso. Com o passar dos dias, possivelmente isto vai ganhar mais espaço. Afinal, só tem vantagem. Aqui, mais uma evidência, apenas 3 horas por semana diminuem em 22% o risco de infarto agudo do miocárdio… Let’s train!
Vigorous physical activity, mediating biomarkers, and risk of myocardial infarction.
Chomistek, Andrea K.; Chiuve, Stephanie E.; Jensen, Majken K.; Cook, Nancy R.; Rimm, Eric B.
Medicine & Science in Sports & Exercise., POST ACCEPTANCE, 25 March 2011.
Purpose: The effects of physical activity on risk of myocardial infarction (MI) are well documented and may include beneficial changes in blood lipids, inflammatory markers, and insulin sensitivity. The degree to which these and other traditional and nontraditional cardiovascular biomarkers mediate the inverse association between physical activity and risk of MI in men remains unclear.
Methods: We conducted a nested case-control study among 18,225 men in the Health Professionals Follow-up Study followed from 1994 to 2004. A total of 412 men with incident MI were matched 1:2 with control participants on age and smoking status using risk-set sampling. From detailed responses to a modified Paffenbarger physical activity questionnaire, we determined the association between average hours of vigorous-intensity activity (activities requiring METs >= 6) and MI risk.
Results: For a 3-hour per week increase in vigorous-intensity activity, the multivariate relative risk (RR) of MI was 0.78 (95% CI 0.61, 0.98). In models including pre-existing CVD-related conditions, further adjustment for HDL-C, vitamin D, apolipoprotein B, and hemoglobin A1c attenuated the RR by 70% (95% CI 12%, 127%) to a RR of 0.93 (95% CI 0.72, 1.19).
Conclusions: Participating in three hours per week of vigorous-intensity activity is associated with a 22% lower risk of MI among men. This inverse association can be partially explained by beneficial effects of physical activity on HDL-C, vitamin D, apolipoprotein B, and hemoglobin A1c. While the inverse association attributable to these biomarkers is substantial, future research should explore benefits of exercise beyond these biomarkers of risk.